![]() Topical application of oxybuprocaine and tetracaine similarly reduced corneal sensitivity in dogs, but oxybuprocaine was less irritating to the conjunctiva than was tetracaine.ĭiquafosol ophthalmic solution 3 %: a review of its use in dry eye.ĭiquafosol ophthalmic solution 3 % (Diquas(®)) is a P2Y2 receptor agonist that promotes tear fluid and mucin secretion and is currently approved in Japan and South Korea for the treatment of dry eye. ![]() Conjunctival hyperemia and chemosis were detected more frequently in tetracaine-treated eyes than in oxybuprocaine-treated eyes. No significant difference in onset, depth, and duration of corneal anesthesia was found between oxybuprocaine-treated and tetracaine-treated eyes. After instillation of oxybuprocaine, maximal corneal anesthesia (CTT = 0) was achieved within 1 minute, and CTT was significantly decreased from 1 to 45 minutes, compared with the baseline value. CTT changes over time differed significantly between oxybuprocaine-treated and control eyes. The CTT of each eye was measured 1 and 5 minutes after topical application and then at 5-minute intervals until 75 minutes after topical application. Dogs of group 2 (n = 12) received a single drop of 0.4% oxybuprocaine ophthalmic solution in one eye and 1% tetracaine ophthalmic solution in the contralateral eye. Dogs of group 1 (n = 22) received a single drop of 0.4% oxybuprocaine ophthalmic solution in one eye and saline (0.9% NaCl) solution (control treatment) in the contralateral eye. Dogs were assigned to 2 groups, and baseline corneal touch threshold (CTT) was measured bilaterally with a Cochet-Bonnet aesthesiometer. To assess the anesthetic efficacy and local tolerance of topically applied 0.4% oxybuprocaine ophthalmic solution to in dogs and compare its effects with those of 1% tetracaine solution. The chemical components of ophthalmic solutions, such as surfactants and solvents, permeate acrylic IOLs, suggesting the potential for long-term adverse effects of eyedrops in pseudophakic eyes.ĭegree and duration of corneal anesthesia after topical application of 0.4% oxybuprocaine hydrochloride ophthalmic solution in ophthalmically normal dogs.ĭouet, Jean-Yves Michel, Julien Regnier, Alain The IOLs immersed in ophthalmic solutions did not show any change, even after extended incubation. Scanning electron microscopy examination of IOLs incubated in ophthalmic solution components showed intralenticular changes. ![]() The contact angle of Rinderon and Panimycin was similar to that of distilled water. The contact angle of Diclod and Bronuck solutions was the smallest. The IOLs were sectioned and observed by scanning electron microscopy. The IOLs were incubated at 35 degrees C for 2 weeks in undiluted ophthalmic solutions and in 1:10 dilutions of ophthalmic solution components. The solutions were diclofenac sodium (Diclod), bromfenac sodium (Bronuck), betamethasone phosphate (Rinderon), dibekacin sulfate (Panimycin), polysorbate 80 (Tween 20), benzalkonium chloride, chlorobutanol, methylparahydroxybenzoate, and propylparahydroxybenzoate. Measurement of the contact angles of ophthalmic solutions on 3 acrylic IOLs was performed. Department of Opthalmology, Showa University School of Medicine. To investigate the effect of ophthalmic solution components on the surface of acrylic intraocular lenses (IOLs). ![]() ![]() Effect of ophthalmic solution components on acrylic intraocular lenses.Īyaki, Masahiko Nishihara, Hitoshi Yaguchi, Shigeo Koide, Ryohei ![]()
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